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Coartemether induced oxidative stress and hepatic damage in Plasmodium berghei Strain Anka infected mice.

Authors: ANYASOR Godswill , OYEWOLE Isaac , Ogunwenmo, Olusola, Adegoke Ayowole

Publication Type: Journal article

Journal: Bulletin On Environmental Contamination And Toxicology

ISSN Number:

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Abstract

This study investigated the effect of coartemether
on antioxidant and hepatotoxic biomarkers in Plasmodium
berghei infected mice. Erythrocyte, hepatic and
renal superoxide dismutase (2.71 ± 0.51; 1.96 ± 0.87;
2.84 ± 0.22 Units/mg protein respectively) and catalase
(4.10 ± 0.10; 8.25 ± 1.24; 6.28 ± 0.11 Units/mg protein
respectively) activities were significantly (p\0.05) elevated
in ‘‘parasitized and treated’’ (PnT) animals. Renal
glutathione level (19.02 ± 0.20 lg/mL) was elevated in
PnT animals. Glutathione S-transferase and malondialdehyde
levels in hepatic (8.76 ± 0.49 lmol/min/mg; 527.23 ±
24.56 mmol/dL) and renal (3.35 ± 0.30 lmol/min/mg;
464.42 ± 59.13 mmol/dL) tissues were significantly high
(p\0.05) in coartemether-treated animals alone. Plasma
aspartate transferase (9.45 ± 3.59 U/L) and alanine transferase
(5.78 ± 2.36 U/L) were high in PnT animals. Therefore,
data indicates that in the presence of P. berghei,
coartemether could alter the antioxidant status and induce
hepatotoxic damage in mice.

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ANYASOR,G. OYEWOLE,I. Ogunwenmo,,K.O Adegoke,A. . (2012). Coartemether induced oxidative stress and hepatic damage in Plasmodium berghei Strain Anka infected mice., 88 (), 108-108.

ANYASOR,G. OYEWOLE,I. Ogunwenmo,,K.O Adegoke,A. . "Coartemether induced oxidative stress and hepatic damage in Plasmodium berghei Strain Anka infected mice." 88, no (), (2012): 108-108.

ANYASOR,G. and OYEWOLE,I. and Ogunwenmo,,K.O and Adegoke,A. and . (2012). Coartemether induced oxidative stress and hepatic damage in Plasmodium berghei Strain Anka infected mice., 88 (), pp108-108.

ANYASORG, OYEWOLEI, Ogunwenmo,KO, AdegokeA, . Coartemether induced oxidative stress and hepatic damage in Plasmodium berghei Strain Anka infected mice.. 2012, 88 ():108-108.

ANYASOR,Godswill , OYEWOLE,Isaac , Ogunwenmo,,Kayode Olusola, and Adegoke,Ayowole . "Coartemether induced oxidative stress and hepatic damage in Plasmodium berghei Strain Anka infected mice.", 88 . (2012) : 108-108.

[1] A.Godswill O.Isaac O.Kayode Olusola & A.Ayowole , "Coartemether induced oxidative stress and hepatic damage in Plasmodium berghei Strain Anka infected mice." vol.88, no., pp. 108-108, 2012.

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