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Hepatoprotective and in vivo Antioxidant activity of Costus afer leaf extract against acetaminophen-induced hepatotoxicity in rats.

Authors: ANYASOR Godswill , Odunsanya , Ibeneme Audrey

Publication Type: Journal article

Journal: Journal Of Investigational Biochemistry

ISSN Number:

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Abstract

This study investigated the hepatoprotective and in vivo antioxidant activity of orally
administered chloroform and ethanol Costus afer leaf extracts (20 - 60 mg/kg b.w.) on 1 g/kg
b.w. acetaminophen-induced acute hepatic injury in albino rats for 7 days. Result showed no
significant difference in plasma and hepatic superoxide activities. Plasma catalase (CAT)
activity was significantly reduced in 20 and 40 mg/kg chloroform extracts and 20 mg/kg
ethanol extract treated groups. Hepatic CAT activity was reduced significantly at coadministered
20 mg/kg ethanol extract and 1 g/kg ACT treated group. Plasma and hepatic
glutathione levels were elevated significantly in chloroform and ethanol leaf extracts treated
groups. The plasma and liver glutathione S-transferase activity in the chloroform extract
groups were significantly reduced while ethanol leaf extract showed no significant difference.
The plasma and hepatic MDA concentrations in the chloroform and ethanol extracts treated
groups were found reduced. Further studies showed that the reduction in AST and ALT
elevated activities induced by ACT was more profound in ethanol treated groups than
chloroform treated groups. Therefore, findings from this present study indicate that the
chloroform leaf extract possess high antioxidant effect than ethanol leaf extracts while ethanol
leaf extract possess high hepatoprotective potentials than chloroform leaf extract.
© 2013

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ANYASOR,G. Odunsanya,K. Ibeneme,A. . (2013). Hepatoprotective and in vivo Antioxidant activity of Costus afer leaf extract against acetaminophen-induced hepatotoxicity in rats., 2 (), 53-53.

ANYASOR,G. Odunsanya,K. Ibeneme,A. . "Hepatoprotective and in vivo Antioxidant activity of Costus afer leaf extract against acetaminophen-induced hepatotoxicity in rats." 2, no (), (2013): 53-53.

ANYASOR,G. and Odunsanya,K. and Ibeneme,A. and . (2013). Hepatoprotective and in vivo Antioxidant activity of Costus afer leaf extract against acetaminophen-induced hepatotoxicity in rats., 2 (), pp53-53.

ANYASORG, OdunsanyaK, IbenemeA, . Hepatoprotective and in vivo Antioxidant activity of Costus afer leaf extract against acetaminophen-induced hepatotoxicity in rats.. 2013, 2 ():53-53.

ANYASOR,Godswill , Odunsanya,Kofoworola , and Ibeneme,Audrey . "Hepatoprotective and in vivo Antioxidant activity of Costus afer leaf extract against acetaminophen-induced hepatotoxicity in rats.", 2 . (2013) : 53-53.

[1] A.Godswill O.Kofoworola & I.Audrey , "Hepatoprotective and in vivo Antioxidant activity of Costus afer leaf extract against acetaminophen-induced hepatotoxicity in rats." vol.2, no., pp. 53-53, 2013.

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