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Costus afer stem extracts protected against Paracetamol-induced oxidative stress and liver damage in rats.

Authors: ANYASOR Godswill , Matthew Elizabeth, Fadairo Oluwatunmise

Publication Type: Journal article

Journal: Spatula Dd

ISSN Number:

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Abstract

Aim: This study was designed to evaluate the in vivo antioxidant and hepatoprotective potentials of Costus afer stem extracts against
paracetamol induced acute liver injury.
Methods: Fifty male albino rats were randomly distributed into ten groups of five rats each and orally co-administered with varying doses
(20 - 60 mg/kg b.w.) of ethanol stem extract (ETSE), chloroform stem extract (CFSE) and paracetamol (PARA) (1 g/kg b.w.) for 7 days. In
vivo liver and plasma antioxidants and hepatotoxic biomarkers were examined by using spectrophotometric methods.
Results: Antioxidant study indicated no significant difference (p>0.05) in liver and plasma superoxide dismutase (SOD) activities in all
treated groups compared with untreated control group. Catalase (CAT) activity in co-administered “PARA + ETSE” treated groups were
significantly reduced (p<0> ETSE” treated groups were elevated compared with “PARA + CFSE” and PARA treated groups while the liver and plasma glutathione Stransferase
(GST) activities in “PARA + ETSE” treated groups were reduced compared with “PARA + CFSE” and PARA treated groups.
Liver and plasma malondialdehyde (MDA) concentrations were significantly reduced in “PARA + ETSE” treated group compared with
“PARA + CFSE” and PARA treated groups. Furthermore, “PARA + CFSE” treated groups have reduced plasma aspartate amino transferase
(AST) and alanine amino transferase (ALT) activities compared with “PARA + ETSE” treated groups and PARA treated groups.
Conclusion: This investigation indicates that C. afer ETSE possess a higher antioxidant activity than CFSE while CFSE had a higher
hepatoprotective property against paracetamol-induced tissue damage. Hence, C. afer stem could be exploited in drug discovery process to
identify potential biopharmaceutical agents against oxidative stress related diseases and hepatic disorders.
Key words: Antioxidant; Costus afer; Stem; Hepatotoxicity; Paracetamol.

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ANYASOR,G. Matthew,O.E Fadairo,O. . (1988). Costus afer stem extracts protected against Paracetamol-induced oxidative stress and liver damage in rats., 3 (), 147-147.

ANYASOR,G. Matthew,O.E Fadairo,O. . "Costus afer stem extracts protected against Paracetamol-induced oxidative stress and liver damage in rats." 3, no (), (1988): 147-147.

ANYASOR,G. and Matthew,O.E and Fadairo,O. and . (1988). Costus afer stem extracts protected against Paracetamol-induced oxidative stress and liver damage in rats., 3 (), pp147-147.

ANYASORG, MatthewOE, FadairoO, . Costus afer stem extracts protected against Paracetamol-induced oxidative stress and liver damage in rats.. 1988, 3 ():147-147.

ANYASOR,Godswill , Matthew,Oluwabunmi Elizabeth, and Fadairo,Oluwatunmise . "Costus afer stem extracts protected against Paracetamol-induced oxidative stress and liver damage in rats.", 3 . (1988) : 147-147.

[1] A.Godswill M.Oluwabunmi Elizabeth & F.Oluwatunmise , "Costus afer stem extracts protected against Paracetamol-induced oxidative stress and liver damage in rats." vol.3, no., pp. 147-147, 1988.

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