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Bioactive compounds in Costus afer Ker Gawl. leaves and stem fractions protected against calcium ion-induced mitochondrial membrane permeability transition.

Authors: ANYASOR Godswill , Efemena Obukohwo, Olanipekun O. Adenike

Publication Type: Journal article

Journal: American Journal Of Research In Medical Sciences.

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Abstract

Objective: Costus afer Ker Gawl is an African ethnomedicinal plant used as a therapeutic for the treatment of oxidative stress-related diseases. This study was designed to identify the most active fractions of C. afer leaves and stem against calcium(II) (Ca2+)-induced mitochondrial membrane permeability transition (MPT). Methods: C. afer leaves and stem were extracted using 70% methanol and subsequently subjected to successive solvent partitioning method to separate it into hexane, ethyl acetate, n -butanol, and aqueous fraction of C. afer leaves and stem. Rat liver mitochondrial fractions were isolated using differential centrifugation technique, and mitochondrial MPT was assessed using a spectrophotometric method. Results: Data showed that n -butanol fractions of C. afer leaves and stem exhibited a significantly high inhibition of Ca2+-induced mitochondrial MPT than other test fractions and standard spermine. Conclusion: n -butanol fractions of C. afer leaves and stem possess bioactive compounds with chemoprotective activity against Ca2+-induced mitochondrial MPT. Furthermore, it is suggested that n -butanol fractions of C. afer leaves and stem could be harnessed for bioactive compounds that can be used in the treatment of mitochondria-associated neurodegenerative diseases.

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ANYASOR,G. Efemena,E.O Olanipekun,O.A . (2017). Bioactive compounds in Costus afer Ker Gawl. leaves and stem fractions protected against calcium ion-induced mitochondrial membrane permeability transition., 1 (), 21-21.

ANYASOR,G. Efemena,E.O Olanipekun,O.A . "Bioactive compounds in Costus afer Ker Gawl. leaves and stem fractions protected against calcium ion-induced mitochondrial membrane permeability transition." 1, no (), (2017): 21-21.

ANYASOR,G. and Efemena,E.O and Olanipekun,O.A and . (2017). Bioactive compounds in Costus afer Ker Gawl. leaves and stem fractions protected against calcium ion-induced mitochondrial membrane permeability transition., 1 (), pp21-21.

ANYASORG, EfemenaEO, OlanipekunOA, . Bioactive compounds in Costus afer Ker Gawl. leaves and stem fractions protected against calcium ion-induced mitochondrial membrane permeability transition.. 2017, 1 ():21-21.

ANYASOR,Godswill , Efemena,E. Obukohwo, and Olanipekun,O. Adenike . "Bioactive compounds in Costus afer Ker Gawl. leaves and stem fractions protected against calcium ion-induced mitochondrial membrane permeability transition.", 1 . (2017) : 21-21.

[1] A.Godswill E.E. Obukohwo & O.O. Adenike , "Bioactive compounds in Costus afer Ker Gawl. leaves and stem fractions protected against calcium ion-induced mitochondrial membrane permeability transition." vol.1, no., pp. 21-21, 2017.

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