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Parasitemia and antimalarial induced histological alterations and oxidative stress in infected mice.

Authors: OYEWOLE Isaac , ANYASOR Godswill , Aina, , OGUNNOWO Ayodele , Sorinwa, , Abraham B.e.

Publication Type: Journal article

Journal: Scientific Journal Of Biological Sciences

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Abstract

In lieu of the reports on re-emergence of chloroquine sensitive Plasmodium falciparum, the choice of the drug for the treatment of malaria especially in the endemic areas may not be ruled out. Here, we reported the antioxidative status and histology of some vital organs in mice infected with P. berghei and subsequently treated with chloroquine. The study was a 4 by 10 model design as follows, the control non-infected, the infected (IN) and chloroquine-treated infected (CqTI)/non-infected (CqTNI) mice. The challenged animals were subjected to five days treatment after parasitemia was established using Gemsa stain. Assays were conducted on the animals following standard procedures. The results showed that parasitemia and Chloroquine induced oxidative stress in (IN) and (CqTNI) groups. This was indicated by significant (p<0>

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OYEWOLE,I. ANYASOR,G. Aina,,O. OGUNNOWO,A. Sorinwa,,B. Abraham,B. . (2014). Parasitemia and antimalarial induced histological alterations and oxidative stress in infected mice., 3 (), 38-38.

OYEWOLE,I. ANYASOR,G. Aina,,O. OGUNNOWO,A. Sorinwa,,B. Abraham,B. . "Parasitemia and antimalarial induced histological alterations and oxidative stress in infected mice." 3, no (), (2014): 38-38.

OYEWOLE,I. and ANYASOR,G. and Aina,,O. and OGUNNOWO,A. and Sorinwa,,B. and Abraham,B. and . (2014). Parasitemia and antimalarial induced histological alterations and oxidative stress in infected mice., 3 (), pp38-38.

OYEWOLEI, ANYASORG, Aina,O, OGUNNOWOA, Sorinwa,B, AbrahamB, . Parasitemia and antimalarial induced histological alterations and oxidative stress in infected mice.. 2014, 3 ():38-38.

OYEWOLE,Isaac , ANYASOR,Godswill , Aina,,O.o , OGUNNOWO,Ayodele , Sorinwa,,B.a , and Abraham,B.e. . "Parasitemia and antimalarial induced histological alterations and oxidative stress in infected mice.", 3 . (2014) : 38-38.

[1] O.Isaac A.Godswill A.O.o O.Ayodele S.B.a & A.B.e. , "Parasitemia and antimalarial induced histological alterations and oxidative stress in infected mice." vol.3, no., pp. 38-38, 2014.

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