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Aqueous fraction of Alstonia boonei de Wild leaves suppressed inflammatory responses in carrageenan and formaldehyde induced arthritic rats.

Authors: Omowumi Akinnawo, ANYASOR Godswill , & Osilesi Odutola

Publication Type: Journal article

Journal: Biomedicine And Pharmacotherapy

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Abstract

Alstonia boonie de Wild is an ethnomedical plant used as therapy against inflammatory disorders. This study evaluated the most active anti-inflammatory and anti-oxidant fraction of A. boonei leaves using in vitro and in vivo models. Quantitative phytochemical analysis, anti-protein denaturation and hypotonicity-induced hemolysis of human red blood cell membrane (HRBC), radical scavenging activity assays, carrageenan and formaldehyde-induced inflammation models were carried out. Results showed that aqueous and ethyl acetate fractions of 70% methanol extract of A. boonie leaves contained high quantities of total phenolic and flavonoid compounds compared with hexane and butanol fractions. Aqueous fraction of A. boonie leaves significantly (P<0>

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Omowumi,O.A ANYASOR,G. Osilesi,O. . (2017). Aqueous fraction of Alstonia boonei de Wild leaves suppressed inflammatory responses in carrageenan and formaldehyde induced arthritic rats., 86 (), 95-95.

Omowumi,O.A ANYASOR,G. Osilesi,O. . "Aqueous fraction of Alstonia boonei de Wild leaves suppressed inflammatory responses in carrageenan and formaldehyde induced arthritic rats." 86, no (), (2017): 95-95.

Omowumi,O.A and ANYASOR,G. and Osilesi,O. and . (2017). Aqueous fraction of Alstonia boonei de Wild leaves suppressed inflammatory responses in carrageenan and formaldehyde induced arthritic rats., 86 (), pp95-95.

OmowumiOA, ANYASORG, OsilesiO, . Aqueous fraction of Alstonia boonei de Wild leaves suppressed inflammatory responses in carrageenan and formaldehyde induced arthritic rats.. 2017, 86 ():95-95.

Omowumi,O. Akinnawo, ANYASOR,Godswill , and Osilesi,Odutola . "Aqueous fraction of Alstonia boonei de Wild leaves suppressed inflammatory responses in carrageenan and formaldehyde induced arthritic rats.", 86 . (2017) : 95-95.

[1] O.O. Akinnawo A.Godswill & O.Odutola , "Aqueous fraction of Alstonia boonei de Wild leaves suppressed inflammatory responses in carrageenan and formaldehyde induced arthritic rats." vol.86, no., pp. 95-95, 2017.

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