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Immunosuppressive acidic protein-Haematological correlates in HIV infected subjects.

Authors: ENITAN Samson

Publication Type: Journal article

Journal: Asian Journal Of Medical Sciences

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Abstract

Background: Immunosuppressive Acidic protein (IAP) is a marker of the extent of immune defects occurring in most cancers. Its correlation with CD4 cell count used as an indicator of immune function and disease progression in Human Immuno-deficiency Virus (HIV) infection is not well documented. Method: This cross sectional study examines if IAP levels correlates with immunosupression and haematopathology occurring in HIV/AIDS infection. The study was conducted at the Federal Teaching Hospital, Ido-Ekiti. 105 participants consisting of 85 HIV infected test subjects and 20 control subjects were enrolled into the study. CD4 counts was obtained using SL cyflow machine, IAP levels determined using ELISA kit for human IAP and Full blood count for all participants was obtained using Sysmex KX-21N haematology analyzer. Regression and correlation analysis was done on data using SPSS 28. Results: IAP showed a negative correlation with CD4 count (r= -0.6), (r= -0.9) and (r= -0.2) in the ART, NART and control groups. The pattern of the results was similar with other parameters except in Neutrophils (r= 0.2) (r= 0.3) and (0.1), Eosinophil (r= 0.6) (r= -0.4) and (r= -0.2) and Lymphocyte (r = -0.3) (r= -0.02) and (r= 0.05) in the ART, NART and control groups respectively. Conclusion: This shows that a relationship exists between levels of IAP and immunohaematopathology occurring in HIV infection. Further studies are required to better elucidate the mechanism of increased IAP levels in various stages of HIV infection.

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ENITAN,S. . (0000). Immunosuppressive acidic protein-Haematological correlates in HIV infected subjects., 8 (), 8-8.

ENITAN,S. . "Immunosuppressive acidic protein-Haematological correlates in HIV infected subjects." 8, no (), (0000): 8-8.

ENITAN,S. and . (0000). Immunosuppressive acidic protein-Haematological correlates in HIV infected subjects., 8 (), pp8-8.

ENITANS, . Immunosuppressive acidic protein-Haematological correlates in HIV infected subjects.. 0000, 8 ():8-8.

ENITAN,Samson , . "Immunosuppressive acidic protein-Haematological correlates in HIV infected subjects.", 8 . (0000) : 8-8.

E.Samson , "Immunosuppressive acidic protein-Haematological correlates in HIV infected subjects." vol.8, no., pp. 8-8, 0000.

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