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Effect of Highly Active AntiRetroviral Therapy (HAART) on CD4+ Cell Count and Liver Enzymes in HIV I

Authors: ENITAN Samson

Publication Type: Journal article

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Abstract

Aim: To assess the effect of highly active antiretroviral therapy (HAART) on CD4+ cell count and liver enzymes in HIV-infected patients six months post-therapy based on age and sex distribution. Methods: A cohort of 200 (66 males, 134 females) consenting HAART naÃ¯ve patients, aged between 16 and 65 years with confirmed cases of HIV infection (by Western blot method) at Lokoja, Nigeria having a baseline CD4+ cell counts â‰¤350 cells/Î¼L were initiated on HAART for six months. Two blood samples were collected, one at pre-HAART (baseline) and the other at post-HAART (follow-up) phase. CD4+ cells were counted and liver enzymes levels were evaluated using the PartecÂ® Cyflow Counter and ReflotronÂ® Plus Auto-Analyzer, respectively. Results: The immunological outcome of 6 months HAART shows that there was slight increase (statistically, considered not significant, P>0.05) in the post-HAART meanÂ±SEMCD4+ cell count in the different age and sex strata investigated, when comparison was made with the pre-HAART meanÂ±SEMCD4+ cell count. Also, the post HAART liver function test show that the liver enzymes levels were not significantly (P>0.05) elevated when compared to the baseline values. Conclusion: Six months of HAART repleted CD4+ cell counts of HIV-infected patients of different age and sex strata, with no risk of liver damage.

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ENITAN,S. . (0000). Effect of Highly Active AntiRetroviral Therapy (HAART) on CD4+ Cell Count and Liver Enzymes in HIV I, 0 (), 0-0.

ENITAN,S. . "Effect of Highly Active AntiRetroviral Therapy (HAART) on CD4+ Cell Count and Liver Enzymes in HIV I" 0, no (), (0000): 0-0.

ENITAN,S. and . (0000). Effect of Highly Active AntiRetroviral Therapy (HAART) on CD4+ Cell Count and Liver Enzymes in HIV I, 0 (), pp0-0.

ENITANS, . Effect of Highly Active AntiRetroviral Therapy (HAART) on CD4+ Cell Count and Liver Enzymes in HIV I. 0000, 0 ():0-0.

ENITAN,Samson , . "Effect of Highly Active AntiRetroviral Therapy (HAART) on CD4+ Cell Count and Liver Enzymes in HIV I", 0 . (0000) : 0-0.

E.Samson , "Effect of Highly Active AntiRetroviral Therapy (HAART) on CD4+ Cell Count and Liver Enzymes in HIV I" vol.0, no., pp. 0-0, 0000.

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