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Empirical Review of the Role of Social Determinants in Treatment Outcomes in Drug-Resistant Tuberculosis Patients

Authors: ATULOMAH Nnodimele

Publication Type: Journal article

Journal: Texila International Journal Of Public Health

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Abstract

Background: Globally, success rate recorded for the treatment of drug-resistant TB remains low.
About half of all patients with TB, often, do not complete their treatment schedule with consequent
prolonged infectivity, drug resistance, relapse and death. Social determinants of health among several
factors have been implicated as responsible for poor treatment outcomes.
Objective: This paper reviewed published empirical studies related to drug-resistant TB treatment
outcomes and examined social factors that may explain the dynamics involved in treatment failures
that are likely to be responsible for poor treatment outcomes among DR-TB patients.
Methodology: A review of empirical studies published in the available databases was conducted
through a systematic search of articles indexed in Pub Med, Google Scholar and EMBASE databases.
Pooled estimates of treatment success were computed and factors responsible were reported.
Results: The review revealed that DR-TB treatment success rate varied from between 34.5% to
78.4%. A total of 252 articles were identified through electronic search, 52 were duplicated while 16
were eligible and included in the review. Mainly, resistance to second line drugs, co-morbid
conditions such as HIV, Diabetes Mellitus, male sex, older age, being underweight, positive sputum
smear, presence of cavities in chest X-ray, longer duration of treatment, non-adherence, previous
treatment, were frequently identified factors associated with poor treatment outcome in MDR-TB
patients.
Conclusion: There was a dearth of studies involving social determinants in explaining the
dynamics of poor treatment outcomes among DR-TB patients.

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ATULOMAH,N. . (2020). Empirical Review of the Role of Social Determinants in Treatment Outcomes in Drug-Resistant Tuberculosis Patients, 8 (), 18-18.

ATULOMAH,N. . "Empirical Review of the Role of Social Determinants in Treatment Outcomes in Drug-Resistant Tuberculosis Patients" 8, no (), (2020): 18-18.

ATULOMAH,N. and . (2020). Empirical Review of the Role of Social Determinants in Treatment Outcomes in Drug-Resistant Tuberculosis Patients, 8 (), pp18-18.

ATULOMAHN, . Empirical Review of the Role of Social Determinants in Treatment Outcomes in Drug-Resistant Tuberculosis Patients. 2020, 8 ():18-18.

ATULOMAH,Nnodimele , . "Empirical Review of the Role of Social Determinants in Treatment Outcomes in Drug-Resistant Tuberculosis Patients", 8 . (2020) : 18-18.

[1] A.Nnodimele , "Empirical Review of the Role of Social Determinants in Treatment Outcomes in Drug-Resistant Tuberculosis Patients" vol.8, no., pp. 18-18, 2020.

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