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Oral administered ascorbic acid attenuated dihydroartemisinin anti-plasmodial activity and elicited hepatic injury in Plasmodium berghei strain Anka infected mice

Authors: ANYASOR Godswill

Publication Type: Journal article

Journal: Journal Of Experimental And Integrative Medicine

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Abstract

Objective: This study investigated the effects of oral co-administered ascorbic acid (AA) and dihydroartemisinin (DHA) on
some hepatotoxic biomarkers and parasitaemia counts in Plasmodium berghei Anka strain infected mice for 7 d.
Methods: Twenty four male Swiss albino mice were randomly distributed into six groups; group I: “non-parasitized and
non-treated”(nPnT), group II: “parasitized and non-treated”(PnT), group III: parasitized mice administered 5 mg/kg DHA,
group IV: parasitized mice administered 5 mg/kg AA, group V: parasitized mice co-administered 5 mg/kg DHA+ 5 mg/kg
AA and group VI: parasitized mice administered 25 mg/kg chloroquine (CQ) as standard.
Results: Plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities were significantly (P<0> reduced in AA, DHA and CQ treated mice compared with PnT mice respectively. In addition, parasitized mice co-treated
with DHA+AA had elevated plasma ALT and AST activities compared with DHA treated mice. Further investigation showed
that parasite count/?l blood in PnT, AA and AA+DHA were not significantly (P>0.05) different. However, DHA and CQ
treated mice had significantly reduced parasite count/?l blood at P<0> Conclusion: Thus, data from this study indicated that the AA interferes with the anti-plasmodial activity of DHA and this
condition could predispose the plasmodium infected individual to hepatic injury.

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ANYASOR,G. . (2016). Oral administered ascorbic acid attenuated dihydroartemisinin anti-plasmodial activity and elicited hepatic injury in Plasmodium berghei strain Anka infected mice, 6 (), 139-139.

ANYASOR,G. . "Oral administered ascorbic acid attenuated dihydroartemisinin anti-plasmodial activity and elicited hepatic injury in Plasmodium berghei strain Anka infected mice" 6, no (), (2016): 139-139.

ANYASOR,G. and . (2016). Oral administered ascorbic acid attenuated dihydroartemisinin anti-plasmodial activity and elicited hepatic injury in Plasmodium berghei strain Anka infected mice, 6 (), pp139-139.

ANYASORG, . Oral administered ascorbic acid attenuated dihydroartemisinin anti-plasmodial activity and elicited hepatic injury in Plasmodium berghei strain Anka infected mice. 2016, 6 ():139-139.

ANYASOR,Godswill , . "Oral administered ascorbic acid attenuated dihydroartemisinin anti-plasmodial activity and elicited hepatic injury in Plasmodium berghei strain Anka infected mice", 6 . (2016) : 139-139.

[1] A.Godswill , "Oral administered ascorbic acid attenuated dihydroartemisinin anti-plasmodial activity and elicited hepatic injury in Plasmodium berghei strain Anka infected mice" vol.6, no., pp. 139-139, 2016.

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