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Formulated hexane fraction of Costus afer leaves balm suppressed xylene induced inflammation in rat model.

Authors: ANYASOR Godswill

Publication Type: Journal article

Journal: American Journal Of Physiology, Biochemistry And Pharmacology

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Abstract

Objective: This study was designed to evaluate the effects of topically applied hexane
fraction and aqueous extract of Costus afer leaves balm and cream formula on xylene-induced
ear edema.
Methods: In vitro anti-inflammatory study was carried out using thermally induced protein
denaturation and human erythrocyte membrane stabilization assays while in vivo
anti-inflammatory study was performed using xylene-induced ear edema in rats.
Results: Hexane fraction of C. afer leaves significantly inhibited thermally induced protein
denaturation and stabilized human erythrocyte membrane against hypotonicity-induced
hemolysis when compared with aqueous extract of C. afer leaves. Furthermore, in
vivo study showed that 10% and 20% w/w hexane fraction of C. afer leaves balm formula
at 360 minutes significantly suppressed xylene-induced ear edema by 82.02% (0.16 ±
0.01 mm) and 96.62% (0.03 ± 0.01 mm), respectively, when compared with 10% and 20%
w/w aqueous extract of C. afer leaves cream formula with 55.06% (0.40 ± 0.01 mm) and
67.42% (0.29 ± 0.02 mm) inhibitions, respectively.
Conclusion: The findings from this study revealed that hexane fraction of C. afer leaves
balm formula exhibited higher anti-inflammatory activity against xylene-induced topical
inflammation.

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ANYASOR,G. . (2018). Formulated hexane fraction of Costus afer leaves balm suppressed xylene induced inflammation in rat model., 7 (), 54-54.

ANYASOR,G. . "Formulated hexane fraction of Costus afer leaves balm suppressed xylene induced inflammation in rat model." 7, no (), (2018): 54-54.

ANYASOR,G. and . (2018). Formulated hexane fraction of Costus afer leaves balm suppressed xylene induced inflammation in rat model., 7 (), pp54-54.

ANYASORG, . Formulated hexane fraction of Costus afer leaves balm suppressed xylene induced inflammation in rat model.. 2018, 7 ():54-54.

ANYASOR,Godswill , . "Formulated hexane fraction of Costus afer leaves balm suppressed xylene induced inflammation in rat model.", 7 . (2018) : 54-54.

[1] A.Godswill , "Formulated hexane fraction of Costus afer leaves balm suppressed xylene induced inflammation in rat model." vol.7, no., pp. 54-54, 2018.

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