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Evaluation of the anti-inflammatory activity of Piper guineense Schumach. & Thonn. seeds fractions using in vitro and in vivo models.

Authors: ANYASOR Godswill

Publication Type: Journal article

Journal: Journal Of Biologically Active Products From Nature

ISSN Number:

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Abstract

Piper guineense Schumach. & Thonn. seeds are employed in ethnomedicine practice as
therapy against inflammatory disorders. This study was designed to determine the most active anti-inflammatory
fraction of P. guineense seed using in vitro and in vivo models. Pulverized P. guineense seeds were partitioned
into hexane and aqueous fractions using solvent-solvent partitioning method. Heat-induced protein denaturation,
hypotonicity-induced hemolysis of erythrocyte membrane, anti-proteinase assays and formaldehyde-induced
inflammation rat model were carried out. Results showed that hexane fraction of P. guineense seeds (HFPGS)
significantly (P<0> (P<0> of P. guineense seeds (AFPGS). Furthermore, 100 mg/kg body weight (b.w.) HFPGS significantly (P<0> suppressed 2 % v/v formaldehyde-induced paw thickness in rats by 83.30 ± 0.03 % on the 7th day when
compared with rats treated with 100 mg/kg b.w. AFPGS (34.08 ± 0.02%) and 10 mg/kg b.w. Diclofenac sodium
(66.15 ± 0.05%). In addition, experimental rats treated with HFPGS had significantly (P<0> and aspartate aminotransferase activities and modulated hematological cells when compared with AFPGS rats.
Thus, hexane fraction of P. guineense seeds showed substantial anti-inflammatory activity and could serve as a
viable source for anti-inflammatory agent(s).

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ANYASOR,G. . (2018). Evaluation of the anti-inflammatory activity of Piper guineense Schumach. & Thonn. seeds fractions using in vitro and in vivo models., 8 (), 234-234.

ANYASOR,G. . "Evaluation of the anti-inflammatory activity of Piper guineense Schumach. & Thonn. seeds fractions using in vitro and in vivo models." 8, no (), (2018): 234-234.

ANYASOR,G. and . (2018). Evaluation of the anti-inflammatory activity of Piper guineense Schumach. & Thonn. seeds fractions using in vitro and in vivo models., 8 (), pp234-234.

ANYASORG, . Evaluation of the anti-inflammatory activity of Piper guineense Schumach. & Thonn. seeds fractions using in vitro and in vivo models.. 2018, 8 ():234-234.

ANYASOR,Godswill , . "Evaluation of the anti-inflammatory activity of Piper guineense Schumach. & Thonn. seeds fractions using in vitro and in vivo models.", 8 . (2018) : 234-234.

[1] A.Godswill , "Evaluation of the anti-inflammatory activity of Piper guineense Schumach. & Thonn. seeds fractions using in vitro and in vivo models." vol.8, no., pp. 234-234, 2018.

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