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Chemoprotective activity of aqueous extract of Acalypha wilkesiana against cyclophosphamide-induced toxicity in rats.

Authors: ANYASOR Godswill

Publication Type: Journal article

Journal: Asian Pacific Journal Of Tropical Medicine

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Abstract

Objective: To investigate the protective effect of aqueous leaf extract of Acalypha (A.)
wilkesiana Muell. Arg (Euphorbiaceae) against cyclophosphamide-induced toxicity in albino
rats.
Methods: Twenty male albino rats were randomly divided into five groups of four animals
each. The control group (?) was fed with pellets and distilled water, while group?was
orally administered with only 20 mg/kg cyclophosphamide. Groups ?, ? and?were coadministered
with 20 mg/kg body weight cyclophosphamide and 110, 220 and 440 mg/ kg
body weight A. wilkesiana leaf extract, respectively, for 7 d. After treatment, liver and kidney
function biomarkers, haematological parameters, liver antioxidants, and mitochondrial
membrane permeability transition pore opening were investigated.
Results: A. wilkesiana leaf extract significantly reduced (P<0> increase in plasma aspartate aminotransferase, alanine aminotransferase, creatinine, uric acid
and urea. It increased superoxide dismutase, catalase, glutathione-S-transferase activities
and reduced glutathione levels. It also increased packed cell volume count, hemoglobin
concentration and white blood cell count while inhibiting the induction of mitochondrial
swelling.
Conclusions: This study demonstrates that aqueous extract of A. wilkesiana leaf protected
tissues against cyclophosphamide-induced oxidative damage.

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ANYASOR,G. . (2019). Chemoprotective activity of aqueous extract of Acalypha wilkesiana against cyclophosphamide-induced toxicity in rats., 12 (), 409-409.

ANYASOR,G. . "Chemoprotective activity of aqueous extract of Acalypha wilkesiana against cyclophosphamide-induced toxicity in rats." 12, no (), (2019): 409-409.

ANYASOR,G. and . (2019). Chemoprotective activity of aqueous extract of Acalypha wilkesiana against cyclophosphamide-induced toxicity in rats., 12 (), pp409-409.

ANYASORG, . Chemoprotective activity of aqueous extract of Acalypha wilkesiana against cyclophosphamide-induced toxicity in rats.. 2019, 12 ():409-409.

ANYASOR,Godswill , . "Chemoprotective activity of aqueous extract of Acalypha wilkesiana against cyclophosphamide-induced toxicity in rats.", 12 . (2019) : 409-409.

[1] A.Godswill , "Chemoprotective activity of aqueous extract of Acalypha wilkesiana against cyclophosphamide-induced toxicity in rats." vol.12, no., pp. 409-409, 2019.

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