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Hepatoprotective and hematological effects of Justicia secunda Vahl leaves on carbon tetrachloride induced toxicity in rats.

Authors: ANYASOR Godswill

Publication Type: Journal article

Journal: Biotechnic And Histochemistry

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Abstract

Justicia secunda Vahl is an exotic plant that is used to treat medical problems. We investigated the
hepatoprotective and hematological effects of aqueous extracts of J. secunda leaves on carbon
tetrachloride induced toxicity in rats. Leaf extracts were prepared using hot and cold extraction
methods to obtain a hot extract of J. secunda leaves (JSHAE) and a cold extract of J. secunda leaves
(JSCAE). Total phenol and flavonoid measurements and antioxidant assays were performed to
determine the extract with the greater antioxidant activity. JSHAE was the more effective extract
for treatment of carbon tetrachloride (CCl4) induced hepatotoxicity and hepatotoxicity in rats.
Silymarin was used as a standard for comparison. We found that JSHAE contained more total
phenol and flavonoid than JSCAE. JSHAE exhibited significantly greater ferric reducing antioxidant
power and 1,1-diphenyl-2-picryl hydrazyl and thiobarbituric acid scavenging activity than JSCAE.
We also found that in vivo, 100 and 200 mg/kg JSHAE significantly reduced plasma aspartate
aminotransferase, alanine aminotransferase, lactate dehydrogenase and total bilirubin levels
following CCl4 induced toxicity compared to untreated rats. JSHAE treated animals exhibited
white blood cell, red blood cell, hemoglobin, hematocrit, platelet and procalcitonin levels that
were comparable to control animals. Liver sections of rats treated with 200 mg/kg. JSHAE
exhibited no abnormalities.

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ANYASOR,G. . (2020). Hepatoprotective and hematological effects of Justicia secunda Vahl leaves on carbon tetrachloride induced toxicity in rats., 10 (), 1-1.

ANYASOR,G. . "Hepatoprotective and hematological effects of Justicia secunda Vahl leaves on carbon tetrachloride induced toxicity in rats." 10, no (), (2020): 1-1.

ANYASOR,G. and . (2020). Hepatoprotective and hematological effects of Justicia secunda Vahl leaves on carbon tetrachloride induced toxicity in rats., 10 (), pp1-1.

ANYASORG, . Hepatoprotective and hematological effects of Justicia secunda Vahl leaves on carbon tetrachloride induced toxicity in rats.. 2020, 10 ():1-1.

ANYASOR,Godswill , . "Hepatoprotective and hematological effects of Justicia secunda Vahl leaves on carbon tetrachloride induced toxicity in rats.", 10 . (2020) : 1-1.

[1] A.Godswill , "Hepatoprotective and hematological effects of Justicia secunda Vahl leaves on carbon tetrachloride induced toxicity in rats." vol.10, no., pp. 1-1, 2020.

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