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Justicia secunda Vahl leaf fraction protects against acetaminophen-induced liver damage in rats by alleviating oxidative stress and enhancing membrane-bound phosphatase activities

Authors: ANYASOR Godswill

Publication Type: Journal article

Journal: Asian Pacific Journal Of Tropical Biomedicine

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Abstract

Objective: To investigate the effect of Justicia secunda Vahl leaf
fraction against acetaminophen-induced oxidative damage in the
liver of rats.
Methods: In vitro antioxidant assays were performed on Justicia
secunda leaf fractions. Gas chromatography-mass spectrometry
analytical method was done. Experimental animals were orally
administered with 2 g/kg b.wt. acetaminophen, 100-500 mg/kg b.wt.
Justicia secunda ethyl acetate leaf fraction (JSELF), and 100 mg/kg
b.wt. silymarin. Blood and liver were collected to measure hepatic,
oxidative stress, and membrane-bound phosphatase markers.
Results: JSELF had significantly (P<0> capacity and inhibition of lipid peroxidation. JSELF-treated animals
had reduced plasma hepatic enzymes, serum C-reactive protein,
and oxidized low-density lipoprotein while hepatic superoxide
dismutase, catalase, and reduced glutathione levels were elevated
compared with untreated control. Membrane-bound phosphatase
activities were improved in JSELF-treated animals. GC-MS detected
tentatively 7 antioxidants and 4 hepatoprotective compounds.
Conclusions: JSELF could protect against oxidative stress and
improve membrane-bound phosphatase activity in rats with
acetaminophen-induced hepatic damage.

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ANYASOR,G. . (2020). Justicia secunda Vahl leaf fraction protects against acetaminophen-induced liver damage in rats by alleviating oxidative stress and enhancing membrane-bound phosphatase activities, 10 (), 479-479.

ANYASOR,G. . "Justicia secunda Vahl leaf fraction protects against acetaminophen-induced liver damage in rats by alleviating oxidative stress and enhancing membrane-bound phosphatase activities" 10, no (), (2020): 479-479.

ANYASOR,G. and . (2020). Justicia secunda Vahl leaf fraction protects against acetaminophen-induced liver damage in rats by alleviating oxidative stress and enhancing membrane-bound phosphatase activities, 10 (), pp479-479.

ANYASORG, . Justicia secunda Vahl leaf fraction protects against acetaminophen-induced liver damage in rats by alleviating oxidative stress and enhancing membrane-bound phosphatase activities. 2020, 10 ():479-479.

ANYASOR,Godswill , . "Justicia secunda Vahl leaf fraction protects against acetaminophen-induced liver damage in rats by alleviating oxidative stress and enhancing membrane-bound phosphatase activities", 10 . (2020) : 479-479.

[1] A.Godswill , "Justicia secunda Vahl leaf fraction protects against acetaminophen-induced liver damage in rats by alleviating oxidative stress and enhancing membrane-bound phosphatase activities" vol.10, no., pp. 479-479, 2020.

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