Efficacy of prophylactic use of intraoperative vancomycin powder in preventing surgical site infection in neurological surgeries in Irrua, Nigeria: A randomized controlled study
Authors: MORGAN Eghosa
Journal: Journal of Clinical Neuroscience
ISSN Number:
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Abstract
Purpose: The objective was to determine the efficacy of intraoperative vancomycin powder in preventing SSIs in
neurological surgeries.
Methods: A prospective randomized controlled study of patients who had clean cranial and non-implant spine
surgeries at the Irrua Specialist Teaching Hospital, Irrua, Nigeria from February 1, 2021 to January 31, 2022.
Patients were randomized into two groups. Group A patients had prophylactic intraoperative vancomycin
powder applied to the surgical bed before wound closure while group B patients did not. Patients in both groups
were followed up for 30 days post-operatively for evidence of SSI. The occurrence of SSIs was determined using
clinical and laboratory parameters. Baseline characteristics, operative details, rates of wound infection, and
microbiological data for each case were recorded. Data was analyzed using Statistical Package for Scientific
Solution (SPSS) version 23 software.
Results: Forty–two patients were randomized into 2 groups of 21 patients each. The age range of the patients was
20 to 80 years. The majority of the patients were males (32 out of 42). The mean age of patients in group A was
48.05 ± 17.03 years, while group B had a mean age of 45.95 ± 19.14 years. The mean Body Mass Index of
patients in groups A and B were 23.92 ± 5.21 and 23.21 ± 3.99 respectively.
Seven out of 21 patients (33.3 %) in the control group ( group B) had superficial SSIs while no patient in the
experimental group had SSI, p-value < 0.05. The organisms cultured were Klebsiella pneumoniae, Pseudomonas
aeruginosa, and Staphylococcus aureus.
Conclusion: Intraoperative vancomycin powder was effective in reducing the rate of SSIs following neurological
surgeries and without adverse drug reactions.
