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Chemoprotective activity of aqueous leaf extract of Acalypha wilkesiana against cyclophosphamide-induced toxicity in rats

Authors: ANOKWURU Chinedu , ANYASOR Godswill , SHOKUNBI Olutayo , Sopekan , Osinuga , Afolabi , Arojojoye , Ezekiel Chibundu , Ramaite Isaiah

Publication Type: Journal article

Journal: Asian Pacific Journal Of Tropical Medicine

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Abstract

Objective: To investigate the protective effect of aqueous leaf extract of Acalypha (A.) wilkesiana Muell. Arg (Euphorbiaceae) against cyclophosphamide-induced toxicity in albino rats.
Methods: Twenty male albino rats were randomly divided into five groups of four animals each. The control group (I) was fed with pellets and distilled water, while group II was orally administered with only 20 mg/kg cyclophosphamide. Groups III, IV and V were coadministered with 20 mg/kg body weight cyclophosphamide and 110, 220 and 440 mg/ kg body weight A. wilkesiana leaf extract, respectively, for 7 d. After treatment, liver and kidney function biomarkers, haematological parameters, liver antioxidants, and mitochondrial membrane permeability transition pore opening were investigated.
Results: A. wilkesiana leaf extract significantly reduced (P<0> Conclusions: This study demonstrates that aqueous extract of A. wilkesiana leaf protected tissues against cyclophosphamide-induced oxidative damage.

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ANOKWURU,C. ANYASOR,G. SHOKUNBI,O. Sopekan,B. Osinuga,O. Afolabi,O. Arojojoye,O. Ezekiel,C. Ramaite,I. . (2019). Chemoprotective activity of aqueous leaf extract of Acalypha wilkesiana against cyclophosphamide-induced toxicity in rats, 12 (), 409-409.

ANOKWURU,C. ANYASOR,G. SHOKUNBI,O. Sopekan,B. Osinuga,O. Afolabi,O. Arojojoye,O. Ezekiel,C. Ramaite,I. . "Chemoprotective activity of aqueous leaf extract of Acalypha wilkesiana against cyclophosphamide-induced toxicity in rats" 12, no (), (2019): 409-409.

ANOKWURU,C. and ANYASOR,G. and SHOKUNBI,O. and Sopekan,B. and Osinuga,O. and Afolabi,O. and Arojojoye,O. and Ezekiel,C. and Ramaite,I. and . (2019). Chemoprotective activity of aqueous leaf extract of Acalypha wilkesiana against cyclophosphamide-induced toxicity in rats, 12 (), pp409-409.

ANOKWURUC, ANYASORG, SHOKUNBIO, SopekanB, OsinugaO, AfolabiO, ArojojoyeO, EzekielC, RamaiteI, . Chemoprotective activity of aqueous leaf extract of Acalypha wilkesiana against cyclophosphamide-induced toxicity in rats. 2019, 12 ():409-409.

ANOKWURU,Chinedu , ANYASOR,Godswill , SHOKUNBI,Olutayo , Sopekan,Babajide , Osinuga,Oyindamola , Afolabi,Olusola , Arojojoye,Olamide , Ezekiel,Chibundu , and Ramaite,Isaiah . "Chemoprotective activity of aqueous leaf extract of Acalypha wilkesiana against cyclophosphamide-induced toxicity in rats", 12 . (2019) : 409-409.

[1] A.Chinedu A.Godswill S.Olutayo S.Babajide O.Oyindamola A.Olusola A.Olamide E.Chibundu & R.Isaiah , "Chemoprotective activity of aqueous leaf extract of Acalypha wilkesiana against cyclophosphamide-induced toxicity in rats" vol.12, no., pp. 409-409, 2019.

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